What Are the Histological Implications of Nek2 Kinase?
In the context of histology, the expression and activity of Nek2 kinase can be observed in tissues undergoing rapid cell division, such as in embryonic development, epithelial tissues, and certain cancerous tissues. Abnormalities in Nek2 expression or function can lead to histopathological changes, including aneuploidy, centrosome amplification, and aberrant mitotic figures. These changes can be detected using various histological techniques, including immunohistochemistry, where specific antibodies against Nek2 are used to visualize its distribution within tissue sections.
