What Are the Clinical Relevance and Potential Therapeutic Targets?
Aberrant expression of Nek2 kinase has been implicated in several types of cancer, including breast, prostate, and colorectal cancers. Overexpression of Nek2 is often associated with poor prognosis and increased tumor aggressiveness. As a result, Nek2 kinase is being explored as a potential therapeutic target. Inhibitors of Nek2 kinase are currently being investigated for their efficacy in disrupting cancer cell proliferation and inducing apoptosis. Understanding the role of Nek2 in cancer can aid in the development of targeted therapies and improve histopathological diagnostic practices.
