What Are the Histological Features of Polycythemia Vera?
Polycythemia vera is characterized by an increase in red blood cell mass. Histologically, both the bone marrow and peripheral blood smears show increased numbers of erythroid, granulocytic, and megakaryocytic cells. The bone marrow biopsy usually demonstrates hypercellular marrow with prominent erythroid hyperplasia and clustering of enlarged megakaryocytes. The presence of the JAK2 V617F mutation is common in PV patients.
