What Are the Histological Features of Essential Thrombocythemia?
In essential thrombocythemia, the bone marrow biopsy reveals increased and often clustered megakaryocytes with abundant, mature cytoplasm. The peripheral blood smear shows a significant increase in the number of platelets, which may be abnormally large. The JAK2 V617F mutation, as well as mutations in the CALR and MPL genes, are frequently associated with ET.
