What Are the Histological Features of Primary Myelofibrosis?
Primary myelofibrosis is characterized by the replacement of bone marrow with fibrous tissue. In early stages, the bone marrow biopsy shows hypercellularity with increased atypical megakaryocytes. As the disease progresses, fibrosis becomes more pronounced, leading to a hypocellular marrow with extensive reticulin and collagen deposition. The peripheral blood smear often demonstrates leukoerythroblastosis, with the presence of nucleated red blood cells and immature granulocytes.
