Histology grading is performed by examining tissue samples under a microscope. The samples are typically stained to highlight key structures and cellular details. Pathologists then evaluate various features, including:
- Cell differentiation: How much the cancer cells resemble normal cells. - Nuclear features: Size, shape, and appearance of the cell nuclei. - Mitotic rate: The number of cells undergoing division. - Architectural pattern: The structural organization of the tissue.
Based on these features, the tissue is assigned a grade, often on a scale of 1 to 4, with higher grades indicating more aggressive and less differentiated cells.
