How Does Histology Contribute to Diagnosis and Treatment?

Histological examination is crucial for the initial diagnosis and classification of MPNs. It helps in distinguishing between different types of MPNs and other hematological disorders. Histology also plays a role in monitoring disease progression and response to treatment. For instance, a decrease in bone marrow fibrosis in PMF patients can indicate a positive response to therapy. Molecular testing for specific mutations, in conjunction with histological findings, further refines the diagnosis and guides targeted therapy.