What Are the Histological Features of Chronic Myeloid Leukemia?
In chronic myeloid leukemia, the bone marrow biopsy shows marked hypercellularity with a predominance of granulocytic precursors. The peripheral blood smear often reveals a left shift, increased basophils, and eosinophils. The presence of the Philadelphia chromosome (BCR-ABL1 fusion gene) is a hallmark of CML and can be detected using cytogenetic or molecular techniques.
