How Do Long Non-Coding RNAs Affect Cellular Processes?
Long non-coding RNAs (lncRNAs) are ncRNAs longer than 200 nucleotides and are involved in a variety of cellular processes including chromatin remodeling, transcriptional regulation, and post-transcriptional modifications. lncRNAs can act as molecular scaffolds, guiding protein complexes to specific genomic loci, or as decoys that sequester regulatory molecules. For example, the lncRNA HOTAIR is known to interact with Polycomb Repressive Complex 2 (PRC2), leading to chromatin modifications and gene silencing.
