SGLT proteins are found in specific tissues throughout the body. The most well-known types, SGLT1 and SGLT2, are primarily located in the small intestine and the kidneys, respectively. In the small intestine, SGLT1 is expressed in the apical membrane of enterocytes, aiding in the absorption of dietary glucose. In the kidneys, SGLT2 is predominant in the proximal convoluted tubule, where it reabsorbs the majority of the filtered glucose from the renal filtrate.