What Role Do MicroRNAs Play in Tissue Homeostasis?
MicroRNAs (miRNAs) are small ncRNAs that regulate gene expression by binding to complementary sequences in target messenger RNAs (mRNAs), leading to mRNA degradation or inhibition of translation. In the context of tissue homeostasis, miRNAs are critical for maintaining cellular functions such as differentiation, proliferation, and apoptosis. For instance, miR-21 is known to be involved in tissue repair and fibrosis, while let-7 family members are important for cellular differentiation and development.
