How Do Non-Coding RNAs Contribute to Cancer Progression?
Non-coding RNAs contribute to cancer progression by regulating key cellular pathways involved in cell proliferation, apoptosis, invasion, and metastasis. miRNAs can function as oncogenes or tumor suppressors depending on their target genes. For example, miR-21 acts as an oncogene by targeting tumor suppressor genes, while miR-34a functions as a tumor suppressor by regulating genes involved in cell cycle control. lncRNAs like H19 and XIST have also been implicated in cancer progression through their roles in epigenetic regulation and gene expression.
