What is the Role of Lipid Mediators in Inflammation?
Lipid mediators play a pivotal role in the initiation, progression, and resolution of inflammation. Pro-inflammatory lipid mediators, such as prostaglandins and leukotrienes, are involved in the recruitment of immune cells to the site of inflammation, increasing vascular permeability, and inducing pain and fever. On the other hand, specialized pro-resolving lipid mediators (SPMs) like resolvins, protectins, and maresins help to resolve inflammation and promote tissue repair.
