Staining is a critical step in histopathology, as it enhances the contrast between different tissue components, making them easier to identify under a microscope. Common stains include Hematoxylin and Eosin (H&E), which are used to differentiate between cell nuclei and cytoplasm. Specialized stains, such as Periodic Acid-Schiff (PAS) and Masson's Trichrome, are used to highlight specific tissue structures or components.