What are the Histological Differences Between Various Neurodegenerative Diseases?
Each neurodegenerative disease has its unique histopathological signature. In Alzheimer's disease, amyloid plaques and neurofibrillary tangles are predominant. In Parkinson's disease, the presence of Lewy bodies within the substantia nigra is a critical feature. ALS is characterized by the loss of motor neurons in the spinal cord, brainstem, and cortex, often with the presence of ubiquitinated protein aggregates.
