Detection of neurodegenerative changes in tissue samples involves a combination of histological staining techniques and immunohistochemistry. Commonly used stains include Hematoxylin and Eosin (H&E) for general tissue structure, and special stains like Congo red or Thioflavin T for amyloid plaques. Immunohistochemistry can be used to detect specific proteins such as beta-amyloid, tau, and alpha-synuclein.
