SGLT1 plays a key role in glucose homeostasis, and its dysfunction can lead to various clinical conditions. For example, mutations in the SGLT1 gene (SLC5A1) can cause a rare disorder known as Glucose-Galactose Malabsorption (GGM), characterized by severe diarrhea and dehydration. Additionally, selective SGLT1 inhibitors are being explored as potential treatments for conditions like type 2 diabetes and obesity.