What is the significance of SGLT1 in renal histology?
In renal histology, SGLT1 is significant due to its role in the reabsorption of glucose in the proximal convoluted tubules. This reabsorption is critical for preventing glucose loss in urine. Under normal conditions, almost all filtered glucose is reabsorbed, but in conditions like diabetes mellitus, the capacity of SGLT transporters can be exceeded, leading to glucosuria (glucose in urine).
