LTD can be induced through various stimulation protocols. One common method is low-frequency stimulation (LFS) of synaptic pathways. This involves stimulating the synapses at a low frequency (typically 1 Hz) for an extended period (10-15 minutes). Another method involves pairing postsynaptic depolarization with low-frequency presynaptic stimulation. The specific protocols can vary, but the general principle involves sustained, low-frequency activity that leads to a lasting decrease in synaptic strength.
