What are the Implications of LTD in Neurological Disorders?

Dysregulation of LTD has been linked to various neurological and psychiatric disorders. For instance, impaired LTD is observed in Alzheimer's disease, where it may contribute to synaptic dysfunction and cognitive deficits. Conversely, excessive LTD has been implicated in depression and schizophrenia, where it may lead to synaptic weakening and disrupted neural circuits. Understanding the mechanisms of LTD could therefore provide insights into the pathophysiology of these disorders and inform potential therapeutic strategies.