Alterations in CYP2J2 expression or function can have significant clinical implications. Overexpression of CYP2J2 has been linked to cardiovascular diseases, such as hypertension, due to the dysregulation of EETs. On the other hand, reduced CYP2J2 activity can impair the metabolism of drugs, leading to increased toxicity or reduced therapeutic efficacy. Understanding the role of CYP2J2 in drug metabolism is crucial for the development of personalized medicine approaches.
