How Do Osteoblasts Interact with Hematopoietic Stem Cells?
Osteoblasts interact with HSCs through direct cell-cell contact and the secretion of signaling molecules. Osteoblasts express cell surface proteins such as N-cadherin and osteopontin, which facilitate adhesion to HSCs. Additionally, osteoblasts secrete factors like CXCL12 (also known as SDF-1) and stem cell factor (SCF), which play crucial roles in HSC homing, retention, and quiescence.
