What are the Key Components of the Osteoblastic Niche?
The osteoblastic niche is composed of several key components, including:
Osteoblasts: These cells are responsible for bone formation and secrete various factors that support HSC maintenance. Hematopoietic Stem Cells (HSCs): These are multipotent stem cells that give rise to various blood cell lineages. Extracellular Matrix (ECM): The ECM provides structural support and biochemical signals important for cell adhesion and communication. Signaling Molecules: These include cytokines, growth factors, and hormones that regulate the activity of cells within the niche.
