What are the Clinical Implications of the Osteoblastic Niche?
Understanding the osteoblastic niche has significant clinical implications. Targeting the niche can offer therapeutic strategies for bone-related diseases, such as osteoporosis, and hematological conditions, like leukemia. For instance, enhancing the supportive capacity of the niche may improve bone regeneration and HSC transplantation outcomes. Conversely, disrupting malignant niches can be a strategy to combat bone metastasis and hematologic malignancies.
