How do Dense Fibrillar Components Interact with Other Nucleolar Components?
The DFC interacts closely with the FC and GC within the nucleolus. The FC is the site of rRNA gene transcription by RNA polymerase I, and the newly synthesized pre-rRNA is immediately processed within the surrounding DFC. The processed rRNA is then transported to the GC, where it undergoes further maturation and assembly into ribosomal subunits. This coordinated interaction ensures efficient ribosome biogenesis, which is essential for protein synthesis and cellular function.
