What is the Significance of Dense Fibrillar Components in Disease?
Alterations in the structure and function of DFCs can be indicative of various diseases, particularly those associated with defects in ribosome biogenesis. For instance, mutations in genes encoding nucleolar proteins can lead to disorders such as ribosomopathies, which are characterized by defects in ribosome production and function. Additionally, changes in nucleolar structure, including the DFC, are often observed in cancer cells, where increased rRNA synthesis supports rapid cell proliferation.
