Several factors can contribute to the loss of rete ridges:
1. Aging: As skin ages, the rete ridges tend to flatten, reducing the overall thickness and strength of the epidermis. 2. Chronic Inflammation: Conditions like chronic dermatitis and psoriasis can lead to the flattening or loss of rete ridges due to persistent inflammation. 3. Autoimmune Disorders: Diseases like lupus and lichen planus can lead to the destruction of rete ridges through autoimmune mechanisms. 4. Infections: Certain infections can damage the epidermal-dermal junction, leading to the loss of rete ridges. 5. Genetic Disorders: Some genetic conditions can impact the formation and maintenance of rete ridges.
