What are the Histological Changes Associated with Calcium Overload?
Histologically, calcium overload can result in several observable changes:
1. Cell Swelling: Due to osmotic imbalances and loss of ATP-dependent ion transport. 2. Mitochondrial Abnormalities: Swollen mitochondria with disrupted cristae can be observed. 3. Nuclear Condensation: A sign of apoptosis resulting from calcium-induced DNA fragmentation. 4. Lysosomal Rupture: Release of lysosomal enzymes into the cytoplasm can cause cellular autolysis.
