What are the Clinical Implications of Calcium Overload?
Calcium overload is implicated in various diseases and conditions:
1. Ischemia-Reperfusion Injury: Sudden restoration of blood flow can cause a surge in calcium influx, leading to cellular damage. 2. Neurodegenerative Diseases: Alzheimer's disease and Parkinson's disease have been linked to dysregulated calcium homeostasis. 3. Cardiac Arrhythmias: Abnormal calcium handling can disrupt normal cardiac rhythms, leading to arrhythmias. 4. Muscle Disorders: Conditions like malignant hyperthermia and muscular dystrophies involve calcium overload in muscle cells.
