What is the Clinical Significance of Bcl-2 Proteins?
The expression levels of Bcl-2 family proteins serve as potential biomarkers for diagnosing and prognosticating various diseases, including cancer. For instance, high levels of Bcl-2 are associated with poor prognosis in certain lymphomas and solid tumors. Therapeutically, inhibitors targeting Bcl-2 proteins, such as Venetoclax, are being used in clinical settings to treat cancers with high Bcl-2 expression.
