Understanding immunomodulation is crucial in histology because it helps in diagnosing and treating various diseases. For instance, in autoimmune diseases, the immune system mistakenly attacks healthy tissues. By studying the histological changes in these tissues, researchers can develop immunosuppressive therapies to control the immune response. Conversely, in cancer, the immune system often fails to recognize and attack cancer cells. Immunotherapy aims to boost the immune response to target and eliminate cancer cells.