thyroid hormone

How is Thyroid Hormone Synthesized?

Thyroid hormone synthesis involves several steps:
Uptake of iodide from the blood.
Oxidation of iodide to iodine by thyroid peroxidase (TPO).
Iodination of tyrosine residues in thyroglobulin to form monoiodotyrosine (MIT) and diiodotyrosine (DIT).
Coupling of MIT and DIT to form T3 and T4.
Following synthesis, the hormones are stored in the colloid and released into the bloodstream upon stimulation by thyroid-stimulating hormone (TSH).

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