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thyroid hormone
How is Thyroid Hormone Synthesized?
Thyroid hormone synthesis involves several steps:
Uptake of
iodide
from the blood.
Oxidation of iodide to iodine by
thyroid peroxidase (TPO)
.
Iodination of tyrosine residues in thyroglobulin to form
monoiodotyrosine (MIT)
and
diiodotyrosine (DIT)
.
Coupling of MIT and DIT to form T3 and T4.
Following synthesis, the hormones are stored in the colloid and released into the bloodstream upon stimulation by
thyroid-stimulating hormone (TSH)
.
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