What Are the Challenges of Adsorption in Histology?
While adsorption is a powerful tool, it comes with its set of challenges: - Non-Specific Binding: Sometimes, stains may adsorb non-specifically to other tissue components, leading to background staining that can obscure diagnostic details. - Optimal Conditions: Finding the right balance of pH, temperature, and concentration can be tricky and often requires empirical adjustments. - Reversibility: Physical adsorption can sometimes be too reversible, leading to fading of stains over time.
