Gamma secretase is a multi-subunit protease complex that plays a crucial role in the cleavage of transmembrane proteins. One of its most well-known substrates is the amyloid precursor protein (APP), which, when cleaved, can lead to the formation of amyloid-beta peptides implicated in Alzheimer's Disease. This complex is also involved in the cleavage of Notch receptors, playing a significant role in various cellular signaling pathways.
