How are Structural Hemoglobin Variants Classified?
Structural hemoglobin variants are classified based on the specific genetic mutations and resulting changes in the globin chain structure. Some common classifications include:
Hemoglobin S (HbS): The most well-known variant, associated with sickle cell disease, caused by a mutation in the β-globin chain. Hemoglobin C (HbC): Another β-globin variant, often leading to a mild hemolytic anemia. Hemoglobin E (HbE): A variant common in Southeast Asia, associated with a mild form of β-thalassemia. Hemoglobin D (HbD): Variants such as HbD-Punjab can lead to mild hemolytic anemia.
