In the kidneys, uremia leads to specific histological changes such as glomerulosclerosis and tubular atrophy. The glomeruli, which are the filtering units of the kidney, become scarred and hardened. This is known as glomerulosclerosis. The renal tubules, responsible for reabsorbing essential substances, become atrophic and lose their functionality. These changes can be visualized using special stains like Periodic Acid-Schiff (PAS) stain, which highlights the basement membrane and other structural components.
