What is the Histological Impact of Hemoglobin Variants?
The presence of hemoglobin variants can lead to various histological changes in blood cells and tissues. For example:
Sickle Cell Anemia: In HbS, red blood cells become sickle-shaped, leading to vaso-occlusive crises and tissue ischemia. Hemoglobin C Disease: HbC can cause red blood cells to form target cells, which are cells with a bullseye appearance. Thalassemias: Variants like HbE can result in hypochromic, microcytic anemia with increased red blood cell turnover.
