actin cytoskeleton

What are the Pathological Implications of Actin Cytoskeleton Dysfunction?

Disruptions in the actin cytoskeleton can lead to various pathological conditions:
Cancer: Altered actin dynamics can influence cell migration and invasion, contributing to cancer metastasis.
Cardiovascular Diseases: Mutations in actin or actin-binding proteins can affect heart muscle function, leading to cardiomyopathies.
Neurodegenerative Diseases: Abnormal actin dynamics are implicated in diseases like Alzheimer’s and Parkinson’s.
Immune Disorders: Proper actin function is essential for immune cell motility and function; its dysregulation can lead to immune deficiencies.

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