In histology, nucleotide analogues are primarily used for labeling and tracing cellular activities, particularly in the study of cell division and DNA synthesis. One common application is the use of bromodeoxyuridine (BrdU), a thymidine analogue, which can be incorporated into the DNA of proliferating cells. By using antibodies specific to BrdU, researchers can identify and quantify cells that are in the S-phase of the cell cycle.
