Several nucleotide analogues are widely used in research and clinical settings. Besides BrdU, another frequently used analogue is 5-fluorouracil (5-FU), which is incorporated into RNA and disrupts its function. Azidothymidine (AZT), a thymidine analogue, is used in the treatment of HIV, as it inhibits the reverse transcriptase enzyme, preventing viral replication. Other examples include cytarabine and gemcitabine, which are used in oncology to treat various cancers.
