LELs are identified through [histopathological examination](http://) using tissue biopsies. Common staining techniques such as [Hematoxylin and Eosin](http://) (H&E) are used to visualize the lesions. Immunohistochemistry (IHC) can further aid in characterizing the lymphoid infiltrates, distinguishing between reactive and neoplastic lymphoid cells by using markers such as CD20, CD3, and Ki-67.
