LVH is clinically significant because it can lead to various adverse outcomes. The thickened myocardium can become less compliant, impairing diastolic filling and leading to diastolic dysfunction. Over time, this can progress to heart failure with preserved ejection fraction (HFpEF). Additionally, the hypertrophic myocardium is more susceptible to ischemia due to the increased oxygen demand and potential reduction in coronary blood flow.