Are There Therapeutic Targets Related to Gamma Secretase?
Yes, gamma secretase has been targeted in therapeutic strategies aimed at treating Alzheimer's disease. Gamma secretase inhibitors (GSIs) and modulators have been developed to reduce the production of amyloid-beta peptides. However, due to the enzyme's role in cleaving other essential substrates like Notch, these therapies need to be carefully designed to minimize side effects. Research is ongoing to develop more selective inhibitors and modulators that can effectively target gamma secretase activity in Alzheimer's disease without disrupting its other critical functions.
