What are the Histological Implications of Gamma Secretase Activity?

Histologically, the activity of gamma secretase can be observed through the formation of amyloid plaques in brain tissue samples from Alzheimer's patients. Immunohistochemical staining techniques can be used to detect amyloid-beta peptides and other substrates of gamma secretase, providing insights into the localization and extent of pathological changes. Additionally, studying the distribution and expression levels of gamma secretase components in various tissues can help elucidate their roles in normal physiology and disease.