GLUT2 transporters are prominently expressed in the liver, pancreatic beta cells, intestinal enterocytes, and renal tubular cells. In the liver, they facilitate the uptake and release of glucose during glycogen synthesis and breakdown. In pancreatic beta cells, they play a critical role in glucose sensing and insulin secretion. In the intestines, they help in the absorption of dietary glucose, and in the kidneys, they are involved in glucose reabsorption.