Impairment or dysfunction of GLUT2 transporters can lead to severe metabolic disturbances. For instance, mutations in the gene encoding GLUT2 can result in a rare genetic disorder known as Fanconi-Bickel syndrome, characterized by glycogen storage issues, hepatomegaly, and renal tubular dysfunction. Additionally, reduced GLUT2 activity in the pancreas can affect insulin secretion, contributing to the development of diabetes mellitus.
