GLUT2 transporters are integral to maintaining glucose homeostasis. In the liver, they allow for the rapid uptake of glucose from the blood after a meal and the release of glucose during fasting states. In pancreatic beta cells, GLUT2 acts as a glucose sensor, initiating the secretion of insulin in response to elevated blood glucose levels. In the intestines, GLUT2 aids in the efficient absorption of glucose from digested food, and in the kidneys, it helps reabsorb glucose from the filtrate back into the bloodstream.
