Degranulation is triggered by various stimuli, including:
- Immune Complexes: Interaction with antigens and antibodies can prompt degranulation. - Pathogen Recognition: Microbial products and toxins can activate cells to release their granules. - Allergens: In allergic reactions, allergens bind to IgE antibodies on the surface of mast cells and basophils, causing degranulation. - Chemical Signals: Cytokines and chemokines from other immune cells can induce degranulation.
