What are the implications of CYP2C19 polymorphisms?
CYP2C19 exhibits genetic polymorphisms, which means that there are variations in the gene that can affect its function. Some individuals have polymorphisms that lead to reduced or increased enzyme activity. These variations can significantly impact the metabolism of drugs that are CYP2C19 substrates. For example, individuals with poor metabolizer phenotypes may not effectively activate the prodrug clopidogrel, leading to reduced therapeutic efficacy.
