Degranulation plays a dual role in health and disease:
- Allergic Reactions: In conditions like asthma, hay fever, and anaphylaxis, degranulation of mast cells releases histamines and other mediators, causing symptoms such as swelling, redness, and bronchoconstriction. - Infections: Degranulation helps in the destruction of pathogens. Neutrophils release enzymes and antimicrobial peptides that kill bacteria and fungi. - Chronic Inflammation: Persistent degranulation can contribute to chronic inflammatory diseases like rheumatoid arthritis and chronic obstructive pulmonary disease (COPD).
